My Deep Sky West imaging partner and I have had issues since last night, first with SGP connecting the the TSX driver and then with PhD guide commands not getting to the mount. According to a post in the past couple hours by Bob Denny on the ACP forum, this is probably caused by the recent Windows 10 update intended to address the much publicized CPU security flaws. This update has been causing numerous issues with ASCOM connectivity. There is apparently a workaround that Bob has published on the ACP forum. If you are having equipment function issues that started in the past couple of days for no apparent reason, this could be your problem.
If you have access to the ACP forum, the information is there. Maybe one of the moderators here could get that information posted here as well.