No, not guiding, plate solving to move the telescope.
Yes, you need to specify how close to the target coordinates you wish to point the telescope during plate solve moves. If you specify 0 pixels it will probably take many plate solves I found 50 pixels is usually good enough to get the target towards the middle in a satisfactory manner, but I do photometry where exact centering is not needed.
In Equipment Profile Manager: My settings—
Equipment profile >>Plate solve>>”Attempt to center” --> 5 “times” --> “until error is les that” 50 “pixels (I don’t have a rotator)