I just updated to 2.4.1.10 and now when ever I open SGP it warns we that PinPoint is selected but no catalog is defined. Use the settings button to locate your catalog. PinPoint runs fine stand alone and under solve settings the path is defined. I don’t see a settings button in SGP so I am at a loss at to what this means. But it comes up every time I start SGP.
It’s important to understand that the only thing the profile manager actually does is populate values in the control panel for you (when you create a new sequence with it). Profiles are sequence templates.