Ben - I’m using a QHY183M and a QHY247C.
In both cases I sat down with SGP and took short dark frames at different gain settings and upped the offset until the minimum value in the statistics panel started to come off its lowest value, ending up typically in the range 50-200. Remembering that you need unique calibration files for each setting, I decided on low, medium and high values, which are favorable to stars, galaxies and nebula respectively.
My lowest gain setting would be zero and then one where the read noise about halves and then halves again. In the case of the QHY183, it was 0, 5 and 10. I may bin the 183 with longer focal lengths so I repeated with 2x2 binning and using the same gains, required different (lower) offsets.
I had to go into the camera settings tab in SGP sequencer window to alter the values. In future, with the latest ASCOM 6.5 platform supporting ASCOM properties for gains and offset, it may be possible for Ken and Jared to make it a sequence setting option.